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Article

[Biology and signaling pathways involved in the oncogenesis of desmoid tumors].

Bulletin du cancer - 1 Mar 2020

Salas Sébastien, Chibon Frédéric

Abstract excerpt

Desmoid tumors (TDs) are derived from mesenchymal stem cells and their pathogenesis is strongly linked to the Wingless/Wnt cascade where the deregulation of β-catenin plays a major role. A mutation of the CTNNB1 encoding β-catenin is found in the majority of sporadic TD cases and constitutional mutations of APC have been described in heritable forms in patients with familial adenomatous polyposis (FAP). Estrogens...

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Identifiers

PMID: 31955867
DOI: 10.1016/j.bulcan.2019.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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