Article
Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis.
Molecular medicine (Cambridge, Mass.) - 16 Jan 2020
Wasik Urszula, Kempinska-Podhorodecka Agnieszka, Bogdanos Dimitrios P, Milkiewicz Piotr, Milkiewicz Malgorzata
Abstract excerpt
BACKGROUND & AIMS: Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of biochemistry or clinical presentation from AMA positive ones. Epigenetics play a key role in immune signalling. Two microRNAs (miRs), namely, miR-21 and miR-150 are known to be involved in liver...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.