Article
Alpha-Thalassemia Carrier due to -α3.7 Deletion: Not So Silent.
Acta haematologica - 1 Jan 2020
Gilad Oded, Steinberg-Shemer Orna, Dgany Orly, Krasnov Tanya, Noy-Lotan Sharon, Tamary Hannah, Yacobovich Joanne
Abstract excerpt
BACKGROUND/OBJECTIVE: Alpha-thalassemia is one of the most prevalent genetic diseases, with the -α3.7 deletion being the most common mutation. Molecular studies have suggested mechanisms to explain the mild phenotype of "silent carrier" heterozygotes. However, the correlation between the clinical laboratory picture and the -α3.7 heterozygous state remains unclear, thus we chose to investigate. METHODS: We...
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