Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour.

doi:10.1016/j.bbr.2020.112476

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Article

Monoamine oxidase A genotype and methylation moderate the association of maltreatment and aggressive behaviour.

Behavioural brain research - 16 Mar 2020

Checknita David, Bendre Megha, Ekström Tomas J, Comasco Erika, Tiihonen Jari, Hodgins Sheilagh, Nilsson Kent W

Abstract excerpt

BACKGROUND: The association between childhood maltreatment and subsequent aggressive behaviour is modified by monoamine oxidase A (MAOA) functional polymorphism (MAOA-uVNTR) genotype, MAOA-Long (MAOA-L) in females, MAOA-Short (MAOA-S) in males. Childhood maltreatment is associated with differential DNA methylation in several genes. Consistent with recent proposals, we hypothesized that the association of the...

Topics

Adult
Aggression
Child
Child Abuse
CpG Islands
DNA Methylation
Female
Genotype
Humans
Male
Monoamine Oxidase
Young Adult

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Open in PubMed

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PMID: 31931023
DOI: 10.1016/j.bbr.2020.112476

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