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B-ALL With t(5;14)(q31;q32); IGH-IL3 Rearrangement and Eosinophilia: A Comprehensive Analysis of a Peculiar IGH-Rearranged B-ALL

10 Dec 2019

Abstract excerpt

Background: B-cell acute lymphoblastic leukemia associated with t(5;14)(q31;q32);IGH-IL3 is an exceptional cause of eosinophilia. The IGH enhancer on 14q32 is juxtaposed to the IL3 gene on 5q31, leading to interleukin-3 overproduction and release of mature eosinophils in the blood. Clinical, biological and outcome data are extremely scarce in the literature. Except for eosinophilia, no relevant common feature has...

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PMID: 31921638
DOI: 10.3389/fonc.2019.01374

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