Article
Human CardioChimeras: Creation of a Novel "Next-Generation" Cardiac Cell.
Journal of the American Heart Association - 7 Jan 2020
Firouzi Fareheh, Sinha Choudhury Sarmistha, Broughton Kathleen, Salazar Adriana, Bailey Barbara, Sussman Mark A
Abstract excerpt
Background CardioChimeras produced by fusion of murine c-kit+ cardiac interstitial cells with mesenchymal stem cells promote superior structural and functional recovery in a mouse model of myocardial infarction compared with either precursor cell alone or in combination. Creation of human CardioChimeras (hCCs) represents the next step in translational development of this novel cell type, but new challenges arise...
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