Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach.

Abstract excerpt

The autosomal recessive phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is characterized by defective functioning of the PMM2 enzyme, which is necessary for the conversion of mannose-6-phosphate into mannose-1-phosphate. Here, a computational pipeline was drawn to identify the most significant mutations, and further, we used a virtual screening approach to identify a new lead compound to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Congenital Disorders of Glycosylation
• Share to Molecular Docking Simulation