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Article

IDH mutations in liver cell plasticity and biliary cancer.

Cell cycle (Georgetown, Tex.) - 1 Jan 2014

Saha Supriya K, Parachoniak Christine A, Bardeesy Nabeel

Abstract excerpt

Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer associated with the bile ducts within the liver. These tumors are characterized by frequent gain-of-function mutations in the isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes-that are also common in subsets of neural, haematopoietic and bone tumors, but rare or absent in the other types of gastrointestinal malignancy. Mutant IDH acts through a...

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Share to Bile Duct Neoplasms
Share to Bile Ducts, Intrahepatic
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Isocitrate Dehydrogenase

Source

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Identifiers

PMID: 25485496
DOI: 10.4161/15384101.2014.965054
PMCID: PMC4614372

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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