Article
Identification of KISS1R gene mutations in disorders of non-obstructive azoospermia in the northeast population of China.
Journal of clinical laboratory analysis - 1 Apr 2020
Geng Dongfeng, Zhang Hongguo, Liu Xiangyin, Fei Jia, Jiang Yuting, Liu Ruizhi, Wang Ruixue, Zhang Guirong
Abstract excerpt
BACKGROUND: Non-obstructive azoospermia (NOA), a serious phenotype of male spermatogenesis failure, is a multifactorial disease which is regulated by genetic, epigenetic, and environmental factors. Some gene structural variants have been demonstrated to be related to NOA. Loss-of-function mutations of KISS1R cause normosmic idiopathic hypogonadotropic hypogonadism (IHH) which result in azoospermia at the...
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