Article
Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNAHis mutation.
The Journal of biological chemistry - 24 Jan 2020
Gong Shasha, Wang Xiaoqiong, Meng Feilong, Cui Limei, Yi Qiuzi, Zhao Qiong, Cang Xiaohui, Cai Zhiyi, Mo Jun Qin, Liang Yong, Guan Min-Xin
Abstract excerpt
The deafness-associated m.12201T>C mutation affects the A5-U68 base-pairing within the acceptor stem of mitochondrial tRNAHis The primary defect in this mutation is an alteration in tRNAHis aminoacylation. Here, we further investigate the molecular mechanism of the deafness-associated tRNAHis 12201T>C mutation and test whether the overexpression of the human mitochondrial histidyl-tRNA synthetase gene (HARS2) in...
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