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Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication

15 Nov 2019

Abstract excerpt

Osteosarcoma is an aggressive bone cancer that frequently metastasizes to the lungs. The cytotoxicity of most chemotherapeutics and targeted drugs in the treatment of osteosarcoma is partially lessened. Furthermore, there is a poor response to current chemo- and radiotherapy for both primary lesions and pulmonary metastases of osteosarcoma. There is a clear need to explore promising drug candidates that could...

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PMID: 31803616
DOI: 10.3389/fonc.2019.01232

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