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Article

Genetic variants in circTUBB interacting with smoking can enhance colorectal cancer risk.

Archives of toxicology - 1 Jan 2020

Zhang Ke, Li Shuwei, Gu Dongying, Xu Kaili, Zheng Rui, Xin Junyi, Meng Yixuan, Ben Shuai, Chu Haiyan, Zhang Zhengdong, Shu Yongqian, Du Mulong, Liu Lingxiang, Wang Meilin

Abstract excerpt

Circular RNAs (circRNAs) are an intriguing class of regulatory RNAs involved in the tumorigenesis of many cancers, including colorectal cancer. Mechanistically, circRNAs sponge microRNAs (miRNAs) with specific miRNA response elements (MREs) and compete for regulatory target genes downstream. However, the genetic effects of MREs on colorectal cancer susceptibility remain unclear. The MREs of colorectal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31797002
DOI: 10.1007/s00204-019-02624-1

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