Article
Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.
The Biochemical journal - 23 Dec 2019
Dindo Mirco, Grottelli Silvia, Annunziato Giannamaria, Giardina Giorgio, Pieroni Marco, Pampalone Gioena, Faccini Andrea, Cutruzzolà Francesca, Laurino Paola, Costantino Gabriele, Cellini Barbara
Abstract excerpt
Peroxisomal alanine:glyoxylate aminotransferase (AGT) is responsible for glyoxylate detoxification in human liver and utilizes pyridoxal 5'-phosphate (PLP) as coenzyme. The deficit of AGT leads to Primary Hyperoxaluria Type I (PH1), a rare disease characterized by calcium oxalate stones deposition in the urinary tract as a consequence of glyoxylate accumulation. Most missense mutations cause AGT misfolding, as in...
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