Article
Analysis of NR5A1 in 142 patients with premature ovarian insufficiency, diminished ovarian reserve, or unexplained infertility.
Maturitas - 1 Jan 2020
Jaillard Sylvie, Sreenivasan Rajini, Beaumont Marion, Robevska Gorjana, Dubourg Christèle, Knarston Ingrid M, Akloul Linda, van den Bergen Jocelyn, Odent Sylvie, Croft Brittany, Jouve Guilhem, Grover Sonia R, Duros Solène, Pimentel Céline, Belaud-Rotureau Marc-Antoine, Ayers Katie L, Ravel Célia, Tucker Elena J, Sinclair Andrew H
Abstract excerpt
Ovarian deficiency, including diminished ovarian reserve and premature ovarian insufficiency, represents one of the main causes of female infertility. Little is known of the genetic basis of diminished ovarian reserve, while premature ovarian insufficiency often has a genetic basis, with genes affecting various processes. NR5A1 is a key gene required for gonadal function, and variants are associated with a wide...
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