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Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation

29 Nov 2019

Abstract excerpt

Human iPSC-derived kidney organoids have the potential to revolutionize discovery, but assessing their consistency and reproducibility across iPSC lines, and reducing the generation of off-target cells remain an open challenge. Here, we profile four human iPSC lines for a total of 450,118 single cells to show how organoid composition and development are comparable to human fetal and adult kidneys. Although cell...

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PMID: 31784515
DOI: 10.1038/s41467-019-13382-0

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