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Article

Attenuation and characterization of porcine enteric alphacoronavirus strain GDS04 via serial cell passage.

Veterinary microbiology - 1 Dec 2019

Xu Zhichao, Lin Ying, Zou Chuangchao, Peng Peng, Wu Yanan, Wei Ying, Liu Yuan, Gong Lang, Cao Yongchang, Xue Chunyi

Abstract excerpt

Porcine enteric alphacoronavirus (PEAV) is a newly identified swine enteropathogenic coronavirus that causes watery diarrhea in newborn piglets. In this study, an original, highly virulent PEAV strain GDS04 was serially passaged in Vero cells. The virus titers and sizes of syncytia increased gradually with the cell passages. Newborn piglets were orally inoculated with PEAV P15, P67 and P100. Compared with P15 and...

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Identifiers

PMID: 31767069
DOI: 10.1016/j.vetmic.2019.108489
PMCID: PMC7117411

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