Article
Poor survival after resection of early gastric cancer: extremes of survivorship analysis reveal distinct genomic profile.
The British journal of surgery - 1 Jan 2020
Datta J, Da Silva E M, Kandoth C, Song T, Russo A E, Hernandez J M, Taylor B S, Janjigian Y Y, Tang L H, Solit D B, Strong V E
Abstract excerpt
A subset of patients with early gastric cancer demonstrate early recurrence and poor survival despite margin-negative resection. This study used an extremes-of-survivorship approach to identify an association between TP53 hotspot mutations co-occurring with loss of heterozygosity and unexpectedly poor survival in early gastric cancer. This distinct genomic profile may be a novel biomarker of poor survival in...
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