Article
Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes.
Diabetes care - 1 Jan 2020
Battaglia Manuela, Ahmed Simi, Anderson Mark S, Atkinson Mark A, Becker Dorothy, Bingley Polly J, Bosi Emanuele, Brusko Todd M, DiMeglio Linda A, Evans-Molina Carmella, Gitelman Stephen E, Greenbaum Carla J, Gottlieb Peter A, Herold Kevan C, Hessner Martin J, Knip Mikael, Jacobsen Laura, Krischer Jeffrey P, Long S Alice, Lundgren Markus, McKinney Eoin F, Morgan Noel G, Oram Richard A, Pastinen Tomi, Peters Michael C, Petrelli Alessandra, Qian Xiaoning, Redondo Maria J, Roep Bart O, Schatz Desmond, Skibinski David, Peakman Mark
Abstract excerpt
The clinical diagnosis of new-onset type 1 diabetes has, for many years, been considered relatively straightforward. Recently, however, there is increasing awareness that within this single clinical phenotype exists considerable heterogeneity: disease onset spans the complete age range; genetic susceptibility is complex; rates of progression differ markedly, as does insulin secretory capacity; and complication...
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