Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy

18 Nov 2019

Abstract excerpt

Two crucial questions in neuroscience are how neurons establish individual identity in the developing nervous system and why only specific neuron subtypes are vulnerable to neurodegenerative diseases. In the central nervous system, spinal motor neurons serve as one of the best-characterized cell types for addressing these two questions. In this review, we dissect these questions by evaluating the emerging role of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Anomalies and Fetal Surgery
Share to Neurogenetic and Muscular Disorders Research
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31738166
DOI: 10.7554/elife.50848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multifaceted roles of microRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophyPMID 31738166Read ↗

Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stagesSemantic proximity Read ↗

The role of miRNA in motor neuron diseaseSemantic proximity Read ↗

How to make spinal motor neuronsSemantic proximity Read ↗

MicroRNAs: protective regulators for neuron growth and developmentSemantic proximity Read ↗

Molecular Regulation in Dopaminergic Neuron Development. Cues to Unveil Molecular Pathogenesis and Pharmacological Targets of Neurodegeneration.Semantic proximity Read ↗

mi RNA in spinal muscular atrophy pathogenesis and therapySemantic proximity Read ↗

Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiationSemantic proximity Read ↗

Understanding microRNAs in neurodegenerationSemantic proximity Read ↗

Long non‐coding RNAs in motor neuron development and diseaseSemantic proximity Read ↗

MotomiRs: miRNAs in Motor Neuron Function and DiseaseSemantic proximity Read ↗

A Perturbed MicroRNA Expression Pattern Characterizes Embryonic Neural Stem Cells Derived from a Severe Mouse Model of Spinal Muscular Atrophy (SMA).Semantic proximity Read ↗

MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS ModelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.