Article
Miconazole-tolerant strains of Malassezia pachydermatis generated by culture in medium containing miconazole.
Veterinary dermatology - 1 Apr 2020
Kano Rui, Kamata Hiroshi
Abstract excerpt
BACKGROUND: Tolerance of Malassezia pachydermatis to azole drugs has been reported worldwide, from strains isolated from dogs. Canine Malassezia dermatitis often is treated with shampoos containing 2% miconazole (MCZ) or other topical MCZ products. OBJECTIVES: In the in vitro study herein, it was investigated whether MCZ-induced amino acid substitutions in the lanosterol 14-alpha-demethylase (ERG11) gene 1 lead...
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