Article
Phase 1 Dose-Escalation Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Tofacitinib in Japanese Healthy Volunteers.
Clinical pharmacology in drug development - 1 Jan 2020
Miyoshi So, Krishnaswami Sriram, Toyoizumi Shigeyuki, Nakamura Hiroyuki, Zwillich Samuel H
Abstract excerpt
The aim of the study was to characterize the pharmacokinetics, safety, and tolerability of tofacitinib, an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis in healthy Japanese volunteers, and to compare these outcomes with those of healthy Western volunteers. Twenty-five volunteers (Japanese, n = 16; Western [white], n = 9) were randomized to...
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