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Impact of coexisting gene mutations in EGFR-mutated non-small cell lung cancer before treatment on EGFR T790M mutation status after EGFR-TKIs.

Lung cancer (Amsterdam, Netherlands) - 1 Jan 2020

Takeda Masayuki, Sakai Kazuko, Hayashi Hidetoshi, Tanaka Kaoru, Haratani Koji, Takahama Takayuki, Kato Ryoji, Yonesaka Kimio, Nishio Kazuto, Nakagawa Kazuhiko

Abstract excerpt

OBJECTIVES: The T790M secondary mutation of epidermal growth factor receptor gene (EGFR) is the most common mechanism of acquired resistance to first- or second-generation EGFR tyrosine kinase inhibitors (TKIs). We investigated the association between gene mutation profile in EGFR mutation-positive non-small cell lung cancer (NSCLC) before EGFR-TKI treatment and T790M status after EGFR-TKI treatment. MATERIALS...

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PMID: 31710890
DOI: 10.1016/j.lungcan.2019.10.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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