Article
GNA11 joins GNAQ and GNA14 as a recurrently mutated gene in anastomosing hemangioma.
Virchows Archiv : an international journal of pathology - 1 Mar 2020
Liau Jau-Yu, Tsai Jia-Huei, Lan Jui, Chen Chih-Chi, Wang Ying-Hao, Lee Jen-Chieh, Huang Hsuan-Ying
Abstract excerpt
Anastomosing hemangioma (AH) is a distinct benign vascular tumor that may be histologically confused with an angiosarcoma. Recently, recurrent GNAQ and GNA14 mutations were identified in AH. GNA11, another paralogue of GNAQ and the one that shows the highest degree of homology to GNAQ, has not yet been found to be mutated in AH. In this study, we investigated the clinicopathological and molecular features of 26...
Topics
- Adult
- Aged
- Female
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- Hemangioma
- Humans
- Male
- Middle Aged
- Mutation