Article
Frequent GNAQ and GNA14 Mutations in Hepatic Small Vessel Neoplasm.
The American journal of surgical pathology - 1 Sept 2018
Joseph Nancy M, Brunt Elizabeth M, Marginean Celia, Nalbantoglu ILKe, Snover Dale C, Thung Swan N, Yeh Matthew M, Umetsu Sarah E, Ferrell Linda D, Gill Ryan M
Abstract excerpt
Hepatic small vessel neoplasm (HSVN) is a recently described infiltrative vascular neoplasm of the liver, composed of small vessels. Although the infiltrative nature can mimic angiosarcoma, HSVN are thought to be benign or low-grade neoplasms because they lack cytologic atypia and increased proliferation. To characterize the molecular pathogenesis of HSVN, we performed both targeted panel sequencing and exome...
Topics
- Adult
- Aged
- Female
- GTP-Binding Protein alpha Subunits, Gq-G11
- Humans
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Neoplasms, Vascular Tissue