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Article

Combination of germline variations associated with survival of folinic acid, fluorouracil and irinotecan-treated metastatic colorectal cancer patients.

Pharmacogenomics - 1 Nov 2019

Labriet Adrien, Lévesque Éric, De Mattia Elena, Cecchin Erika, Jonker Derek, Couture Félix, Simonyan David, Buonadonna Angela, D'Andrea Mario, Villeneuve Lyne, Toffoli Giuseppe, Guillemette Chantal

Abstract excerpt

Aim: Germline variants could modify survival of metastatic colorectal cancer patients (mCRC). Patients & methods: The association of 285 haplotype-tagging SNPs in 11 candidate genes and overall survival (OS) was tested in two cohorts totalizing 417 FOLFIRI-treated mCRC. Gene expression was investigated in vitro and in public datasets. Results: In the combined cohort, CES1 rs9921399T>C was associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31698983
DOI: 10.2217/pgs-2019-0091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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