Article
A fit of CD4+ T cell immune response to an infection by lymphocytic choriomeningitis virus.
Mathematical biosciences and engineering : MBE - 1 Aug 2019
Afsar Atefeh, Martins Filipe, Oliveira Bruno M P M, Pinto Alberto A
Abstract excerpt
We fit an immune response model to data reporting the CD4+ T cell numbers from the 28 days following the infection of mice with lymphocytic choriomeningitis virus LCMV. We used an ODE model that was previously used to describe qualitatively the behaviour of CD4+ T cells, regulatory T cells (Tregs) and interleukine-2 (IL-2) density. The model considered two clonotypes of T cells in order to fit simultaneously the...
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