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Article

Metagenomic Nanopore Sequencing of Influenza Virus Direct from Clinical Respiratory Samples

31 Oct 2019

Abstract excerpt

values, 30 to 40). No false-positive reads were generated from 10 influenza virus-negative samples. Thus, Nanopore sequencing operated with 83% sensitivity (95% confidence interval [CI], 67 to 93%) and 100% specificity (95% CI, 69 to 100%) compared to the current diagnostic standard. Coverage of full-length virus was dependent on sample composition, being negatively influenced by increased host and bacterial...

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PMID: 31666364
DOI: 10.1128/jcm.00963-19

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