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T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis

1 Oct 2019

Abstract excerpt

Identifying T cell clones associated with human autoimmunity has remained challenging. Intriguingly, many autoimmune diseases, including multiple sclerosis (MS), show strongly diminished activity during pregnancy, providing a unique research paradigm to explore dynamics of immune repertoire changes during active and inactive disease. Here, we characterize immunomodulation at the single-clone level by sequencing...

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PMID: 31644905
DOI: 10.1016/j.celrep.2019.09.025

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