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Article

New Case Detection by Cascade Testing in Familial Hypercholesterolemia: A Systematic Review of the Literature.

Circulation. Genomic and precision medicine - 1 Nov 2019

Lee Christopher, Rivera-Valerio Miriannie, Bangash Hana, Prokop Larry, Kullo Iftikhar J

Abstract excerpt

BACKGROUND: The prevalence of familial hypercholesterolemia is 1 in 250, but <10% of patients are diagnosed. Cascade testing enables early detection of cases through systematic family tracing. Establishment of familial hypercholesterolemia cascade testing programs in the US could be informed by approaches used elsewhere. METHODS: We conducted a systematic review of published studies in the English language of...

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Identifiers

PMID: 31638829
DOI: 10.1161/CIRCGEN.119.002723
PMCID: PMC9875692

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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