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Architecture of African swine fever virus and implications for viral assembly

17 Oct 2019

Abstract excerpt

African swine fever virus (ASFV) is a giant and complex DNA virus that causes a highly contagious and often lethal swine disease for which no vaccine is available. Using an optimized image reconstruction strategy, we solved the ASFV capsid structure up to 4.1 angstroms, which is built from 17,280 proteins, including one major (p72) and four minor (M1249L, p17, p49, and H240R) capsid proteins organized into...

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PMID: 31624094
DOI: 10.1126/science.aaz1439

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