Article
The role of new β-lactamase inhibitors in gram-negative infections
2 Oct 2019
Abstract excerpt
PURPOSE OF REVIEW: In recent years, traditional β-lactams have dramatically reduced their effectiveness against gram-negative bacteria mainly because of their ability to express multiple β-lactamase or carabapenemases that are not hydrolyzed by the old β-lactam inhibitors (BLIs) such as clavulanic acid, tazobactam, and sulbactam. New BLIs molecules have been developed to face the need of compounds that are active...
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