Astrocyte–microglial association and matrix composition are common events in the natural history of primary familial brain calcification

Abstract excerpt

Abstract Primary familial brain calcification (PFBC) is an age‐dependent and rare neurodegenerative disorder characterized by microvascular calcium phosphate deposits in the deep brain regions. Known genetic causes of PFBC include loss‐of‐function mutations in genes involved in either of three processes—platelet‐derived growth factor (PDGF) signaling, phosphate homeostasis or protein glycosylation—with unclear...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bone and Dental Protein Studies
• Share to Caveolin-1 and cellular processes
• Share to Parathyroid Disorders and Treatments