Article
RET gene rearrangements occur in a subset of pancreatic acinar cell carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2020
Chou Angela, Brown Ian S, Kumarasinghe M Priyanthi, Perren Aurel, Riley Denise, Kim Yoomee, Pajic Marina, Steinmann Angela, Rathi Vivek, Jamieson Nigel B, Verheij Joanne, van Roessel Stijn, Nahm Chris B, Mittal Anubhav, Samra Jaswinder, Gill Anthony J
Abstract excerpt
Pancreatic acinar cell carcinoma is relatively rare (1 to 2% of pancreatic malignancies) but may be under-recognized. In contrast to pancreatic ductal adenocarcinoma, most acinar cell carcinomas lack mutations in KRAS, DPC, CDKN2A or TP53, but appear to have a high incidence of gene rearrangements, with up to 20% reported to be driven by BRAF fusions. With the development of a new class of RET-specific tyrosine...
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