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Article

Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2020

Rotow Julia K, Gui Philippe, Wu Wei, Raymond Victoria M, Lanman Richard B, Kaye Frederic J, Peled Nir, Fece de la Cruz Ferran, Nadres Brandon, Corcoran Ryan B, Yeh Iwei, Bastian Boris C, Starostik Petr, Newsom Kimberly, Olivas Victor R, Wolff Alexander M, Fraser James S, Collisson Eric A, McCoach Caroline E, Camidge D Ross, Pacheco Jose, Bazhenova Lyudmila, Li Tianhong, Bivona Trever G, Blakely Collin M

Abstract excerpt

PURPOSE: Although patients with advanced-stage non-small cell lung cancers (NSCLC) harboring MET exon 14 skipping mutations (METex14) often benefit from MET tyrosine kinase inhibitor (TKI) treatment, clinical benefit is limited by primary and acquired drug resistance. The molecular basis for this resistance remains incompletely understood. EXPERIMENTAL DESIGN: Targeted sequencing analysis was performed on...

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Identifiers

PMID: 31548343
DOI: 10.1158/1078-0432.CCR-19-1667
PMCID: PMC6980768

Genes

MET
KRAS
NF1
EGFR

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