Article
A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research.
Nature medicine - 1 Sept 2019
Poyet M, Groussin M, Gibbons S M, Avila-Pacheco J, Jiang X, Kearney S M, Perrotta A R, Berdy B, Zhao S, Lieberman T D, Swanson P K, Smith M, Roesemann S, Alexander J E, Rich S A, Livny J, Vlamakis H, Clish C, Bullock K, Deik A, Scott J, Pierce K A, Xavier R J, Alm E J
Abstract excerpt
Our understanding of how the gut microbiome interacts with its human host has been restrained by limited access to longitudinal datasets to examine stability and dynamics, and by having only a few isolates to test mechanistic hypotheses. Here, we present the Broad Institute-OpenBiome Microbiome Library (BIO-ML), a comprehensive collection of 7,758 gut bacterial isolates paired with 3,632 genome sequences and...
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