Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Companion gene mutations and their clinical significance in AML with double mutant CEBPA.

Cancer gene therapy - 1 Aug 2020

Zhang Yang, Wang Fang, Chen Xue, Zhang Yu, Wang Mingyu, Liu Hong, Teng Wen, Cao Panxiang, Nie Daijing, Ma Xiaoli, Wang Tong, Lu Peihua, Liu Hongxing

Abstract excerpt

Acute myeloid leukemia (AML) with double mutant CEBPA (CEBPAdm) is generally associated with favorable prognosis, but the heterogeneity still blatant and needs further exploration. We aimed to comprehensively analyze the companion genetic abnormalities and their clinical significance in AML patients with CEBPAdm. By performed targeted amplicon sequencing of 58 genes in specimens at the time of initial diagnosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Source

Identifiers

PMID: 31477806
DOI: 10.1038/s41417-019-0133-7

Genes

CSF3R
GATA2
JAK3
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Companion gene mutations and their clinical significance in AML with double mutant CEBPAPMID 31477806Read ↗

Companion gene mutations and their clinical significance in AML with double or single mutant CEBPA.Semantic proximity Read ↗

Concomitant WT1 mutations predict poor prognosis in acute myeloid leukemia patients with double mutant CEBPASemantic proximity Read ↗

Mutational spectrum of acute myeloid leukemia patients with double CEBPA mutations based on next-generation sequencing and its prognostic significanceSemantic proximity Read ↗

JAKed up phenotype of CEBPA-mutant AML.Semantic proximity Read ↗

CSF3R mutations were associated with an unfavorable prognosis in patients with acute myeloid leukemia with CEBPA double mutationsSemantic proximity Read ↗

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity.Semantic proximity Read ↗

Acute Myeloid Leukemia With Biallelic CEBPA Gene Mutations and Normal Karyotype Represents a Distinct Genetic Entity Associated With a Favorable Clinical OutcomeSemantic proximity Read ↗

Acute Myeloid Leukemia With CEBPA Mutations: Current Progress and Future DirectionsSemantic proximity Read ↗

A case of acute myeloid leukemia with unusual germline CEBPA mutation: lessons learned about mutation detection, location, and penetrance.Semantic proximity Read ↗

The clinical characteristics and prognosis of cytogenetically normal AML with single mutations of CEBPA.Semantic proximity Read ↗

Sporadic and Familial Acute Myeloid Leukemia with CEBPA Mutations.Semantic proximity Read ↗

Clonal Evolution of Acute Myeloid Leukemia with CEBPA Double Mutations after Long-Term Remission: Case Report and a Literature ReviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.