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Article

Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells.

Nature reviews. Cancer - 1 Oct 2019

Keller Laura, Pantel Klaus

Abstract excerpt

Single-cell technologies have contributed to unravelling tumour heterogeneity, now considered a hallmark of cancer and one of the main causes of tumour resistance to cancer therapies. Liquid biopsy (LB), defined as the detection and analysis of cells or cell products released by tumours into the blood, offers an appealing minimally invasive approach that allows the characterization and monitoring of tumour...

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PMID: 31455893
DOI: 10.1038/s41568-019-0180-2

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