Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.

doi:10.1038/s41375-019-0541-6

Article

Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma.

Leukemia - 1 Jan 2020

Desch Ann-Kathrin, Hartung Kristin, Botzen Ante, Brobeil Alexander, Rummel Mathias, Kurch Lars, Georgi Thomas, Jox Theresa, Bielack Stefan, Burdach Stefan, Classen Carl Friedrich, Claviez Alexander, Debatin Klaus-Michael, Ebinger Martin, Eggert Angelika, Faber Jörg, Flotho Christian, Frühwald Michael, Graf Norbert, Jorch Norbert, Kontny Udo, Kramm Christof, Kulozik Andreas, Kühr Joachim, Sykora Karl-Walter, Metzler Markus, Müller Hermann L, Nathrath Michaela, Nüßlein Thomas, Paulussen Michael, Pekrun Arnulf, Reinhardt Dirk, Reinhard Harald, Rössig Claudia, Sauerbrey Axel, Schlegel Paul-Gerhardt, Schneider Dominik T, Scheurlen Wolfram, Schweigerer Lothar, Simon Thorsten, Suttorp Meinolf, Vorwerk Peter, Schmitz Roland, Kluge Regine, Mauz-Körholz Christine, Körholz Dieter, Gattenlöhner Stefan, Bräuninger Andreas

Abstract excerpt

We used hybrid capture-targeted next-generation sequencing of circulating cell-free DNA (ccfDNA) of pediatric Hodgkin lymphoma (PHL) patients to determine pathogenic mechanisms and assess the clinical utility of this method. Hodgkin-Reed/Sternberg (HRS) cell-derived single nucleotide variants, insertions/deletions, translocations and VH-DH-JH rearrangements were detected in pretherapy ccfDNA of 72 of 96 patients....

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