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Article

Truncation of MYH8 tail in AML: a novel prognostic marker with increase cell migration and epithelial–mesenchymal transition utilizing RAF/MAPK pathway

18 Aug 2019

Abstract excerpt

MYH8 is an actin-based motor protin involved in integrin-mediated cell adhesion and migration. Heretofore, the association of MYH8 mutation and cancer is unclear. In this study, we investigated the biologic significance of novel MYH8 tail truncation mutation, R1292X, in acute myeloid leukemia (AML) which was discovered by whole-exome sequencing and targeted re-sequencing of 209 AML patients. The patients...

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PMID: 31430364
DOI: 10.1093/carcin/bgz146

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