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Article

Association between major depressive disorder and multiple disease outcomes: a phenome-wide Mendelian randomisation study in the UK Biobank.

Molecular psychiatry - 1 Jul 2020

Mulugeta Anwar, Zhou Ang, King Catherine, Hyppönen Elina

Abstract excerpt

Depression affects all aspects of an individual's life but evidence relating to the causal effects on health is limited. We used information from 337,536 UK Biobank participants and performed hypothesis-free phenome-wide association analyses between major depressive disorder (MDD) genetic risk score (GRS) and 925 disease outcomes. GRS-disease outcome associations passing the multiple-testing corrected...

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PMID: 31427754
DOI: 10.1038/s41380-019-0486-1

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