Article
Increased Expression of Circulating microRNA 101-3p in Type 1 Diabetes Patients: New Insights Into miRNA-Regulated Pathophysiological Pathways for Type 1 Diabetes
23 Jul 2019
Abstract excerpt
MicroRNAs (miRs) are master regulators of post-transcriptional gene expression, and are dysregulated in diabetes. We investigated the roles of miR-101-3p and miR-204-5p, which negatively regulate insulin secretion and cell survival and are highly expressed in pancreatic β cells, in type 1 diabetes (T1D) pathogenesis. Using quantitative real time PCR, we evaluated serum levels of miR-101-3p and miR-204-5p in four...
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