Article
Determining Possible Shared Genetic Architecture Between Myopia and Primary Open-Angle Glaucoma.
Investigative ophthalmology & visual science - 1 Jul 2019
Iglesias Adriana I, Ong Jue Sheng, Khawaja Anthony P, Gharahkhani Puya, Tedja Milly S, Verhoeven Virginie J M, Bonnemaijer Pieter W M, Wolfs Roger C W, Young Terri L, Jansonius Nomdo M, Craig Jamie E, Stambolian Dwight, van Duijn Cornelia M, MacGregor Stuart, Klaver Caroline C W
Abstract excerpt
Purpose: To determine genetic correlations between common myopia and primary open-angle glaucoma (POAG). Methods: We tested the association of myopia polygenic risk scores (PRSs) with POAG and POAG endophenotypes using two studies: the Australian & New Zealand Registry of Advanced Glaucoma (ANZRAG) study comprising 798 POAG cases with 1992 controls, and the Rotterdam Study (RS), a population-based study with...
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