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Human Cytomegalovirus Compromises Development of Cerebral Organoids

14 Jun 2019

Abstract excerpt

Human cytomegalovirus (HCMV) is a leading cause of central nervous system birth defects, ranging from microcephaly to hearing impairment. Recent literature has provided descriptions of delayed and abnormal maturation of developing cortical tissue in infected clinical specimens. We have found that infected induced pluripotent stem cells can be differentiated into three-dimensional, viral protein-expressing...

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PMID: 31217239
DOI: 10.1128/jvi.00957-19

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