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Article

Novel Role for miR-1290 in Host Species Specificity of Influenza A Virus

15 May 2019

Abstract excerpt

The role of microRNA (miRNA) in influenza A virus (IAV) host species specificity is not well understood as yet. Here, we show that a host miRNA, miR-1290, is induced through the extracellular signal-regulated kinase (ERK) pathway upon IAV infection and is associated with increased viral titers in human cells and ferret animal models. miR-1290 was observed to target and reduce expression of the host vimentin gene....

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PMID: 31173947
DOI: 10.1016/j.omtn.2019.04.028

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