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Polysomy is associated with poor outcome in 1p/19q codeleted oligodendroglial tumors

28 May 2019

Abstract excerpt

BACKGROUND: Chromosomal instability is associated with earlier progression in isocitrate dehydrogenase (IDH)-mutated astrocytomas. Here we evaluated the prognostic significance of polysomy in gliomas tested for 1p/19q status. METHODS: We analyzed 412 histologic oligodendroglial tumors with use of 1p/19q testing at 8 institutions from 1996 to 2013; fluorescence in situ hybridization (FISH) for 1p/19q was...

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PMID: 31140557
DOI: 10.1093/neuonc/noz098

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