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Staphylococcus aureus induces DNA damage in host cell

22 May 2019

Abstract excerpt

Abstract Staphylococcus aureus causes serious medical problems in human and animals. Here we show that S. aureus can compromise host genomic integrity as indicated by bacteria-induced histone H2AX phosphorylation, a marker of DNA double strand breaks (DSBs), in human cervix cancer HeLa and osteoblast-like MG-63 cells. This DNA damage is mediated by alpha phenol-soluble modulins (PSMα1–4), while a specific class...

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PMID: 31118484
DOI: 10.1038/s41598-019-44213-3

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