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Article

The general stress response of Staphylococcus aureus promotes tolerance of antibiotics and survival in whole human blood.

Microbiology (Reading, England) - 1 Nov 2020

Ranganathan Nisha, Johnson Rebecca, Edwards Andrew M

Abstract excerpt

Staphylococcus aureus is a frequent cause of invasive human infections such as bacteraemia and infective endocarditis. These infections frequently relapse or become chronic, suggesting that the pathogen has mechanisms to tolerate the twin threats of therapeutic antibiotics and host immunity. The general stress response of S. aureus is regulated by the alternative sigma factor B (σB) and provides protection from...

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Identifiers

PMID: 33095698
DOI: 10.1099/mic.0.000983
PMCID: PMC7723259

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