Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography

Abstract excerpt

Redox cycling of iron powers various enzyme functions crucial for life, making the study of iron acquisition, storage, and disposition in the whole organism a worthy topic of inquiry. However, despite its important role in biology and disease, imaging iron in animals with oxidation-state specificity remains an outstanding problem in biology and medicine. Here we report a first-generation reactivity-based probe of...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Iron Metabolism and Disorders
• Share to Radiopharmaceutical Chemistry and Applications
• Share to Trace Elements in Health