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Clostridium difficile trehalose metabolism variants are common and not associated with adverse patient outcomes when variably present in the same lineage

26 Apr 2019

Abstract excerpt

BACKGROUND: Clostridium difficile ribotype-027, ribotype-078, and ribotype-017 are virulent and epidemic lineages. Trehalose metabolism variants in these ribotypes, combined with increased human trehalose consumption, have been hypothesised to have contributed to their emergence and virulence. METHODS: 5232 previously whole-genome sequenced C. difficile isolates were analysed. Clinical isolates were used to...

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PMID: 31036529
DOI: 10.1016/j.ebiom.2019.04.038

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