Article
Emergence of a ribotype 244 strain of Clostridium difficile associated with severe disease and related to the epidemic ribotype 027 strain.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Jun 2014
Lim Sze K, Stuart Rhonda L, Mackin Kate E, Carter Glen P, Kotsanas Despina, Francis Michelle J, Easton Marion, Dimovski Karolina, Elliott Briony, Riley Thomas V, Hogg Geoff, Paul Eldho, Korman Tony M, Seemann Torsten, Stinear Timothy P, Lyras Dena, Jenkin Grant A
Abstract excerpt
BACKGROUND: We identified 12 patients with Clostridium difficile infection between July 2011 and March 2012 from whom an unusual C. difficile strain was isolated. This strain had a single-nucleotide deletion of the tcdC gene at position 117 and binary toxin genes, which are characteristic of the hypervirulent ribotype (RT) 027 strain. METHODS: A retrospective cohort study of 12 patients infected with C. difficile...
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